He began developing his mnemonic techniques in 1987 when he saw Creighton Carvello memorize a pack of 52 playing cards in less than three minutes on the BBC television program Record Breakers. In order to memorize numbers, O’Brien developed the mnemonic Dominic system, which is similar to the Major System. He has written books about memorization techniques such as How to Develop a Perfect Memory, Quantum Memory Power, Learn to Remember, How to Pass Exams, The Winning Hand, and The Amazing Memory Box.
He gives lectures and has been seen on television programs such as The Human Body.
Dominic O’Brien had an entry in the Guinness Book of Records for his 1 May 2002 feat of committing to memory a random sequence of 2808 playing cards (54 packs) after looking at each card only once. He was able to correctly recite their order, making only eight errors, four of which he immediately corrected when told he was wrong.