The long track traveled through a number of villages situated on hills surrounding Pescara, following a roughly triangular shape with its corners at the seaside municipality of Pescara. It included two 5.5 km long straights between the seaside municipality of Montesilvano, nicknamed “The Flying Kilometre”.

The highest point, at Spoltore, was 185 m above sea level. The track started just outside the middle of Pescara, moving west through the suburb of Rione Partenze, and then into the hilly villages of Frascone, Valle Carbone, Spoltore, and Case Fornace, going through a mixture of slow and fast bends before dropping out of the hills into the inland municipality of Cappelle sul Tavo, then down the first 5.5 km straight northeast to Montesilvano before going down another 5.5 km straight and returning to Pescara.

The first race took place in 1924 and non-Championship Formula One races followed in the early 1950s, with one official Formula One World Championship event in 1957 due to the cancellation of other races. The Pescara Grand Prix drew in excess of 200,000 spectators, and remains the longest circuit in terms of lap distance ever to stage a Formula One Grand Prix.

According to Wikipedia